(TJV) Researchers at Boston University have created a new strain of Covid-19 that has an 80% kill rate in humanized mice.
In an effort to research what makes Omicron so transmissible – and funded in part by grants from the NIH and Anthony Fauci’s NIAID, the researchers cobbled the Omicron spike protein to the original strain of Covid-19. The resulting virus was five times more infectious than Omicron, Daily Mail reported.
The new research, which has not been peer-reviewed, was conducted by a team from Boston and Florida, Zero Hedge reported.
“In…mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80 percent,” the researchers wrote, adding that while the spike protein is responsible for infectivity, changes to other parts of its structure are responsible for its deadliness.
How many times did virologists say they were not making chimeric SARS viruses more deadly? How many???
Latest preprint shows they made a chimeric SARS-CoV-2 w/ Omicron S gene and ancestral SARS-CoV-2 backbone that showed 80% mortality in humanised mice. pic.twitter.com/KVYGTXPb7E
— Paul D. Thacker (@thackerpd) October 17, 2022
Researchers attached Omicron’s spike to the original wildtype strain that first emerged in Wuhan at the start of the pandemic.
The researchers looked at how mice fared against the new hybrid strain compared to the original Omicron variant. –Daily Mail(LINK)
This study provides important insights into Omicron pathogenicity. We show that spike, the single most mutated protein in Omicron, has an incomplete role in Omicron attenuation. In in vitro infection assays, the Omicron spike-bearing ancestral SARS-CoV-2 (Omi-S) exhibits much higher replication efficiency compared with Omicron. Similarly, in K18-hACE2 mice, Omi-S contrasts with non-fatal Omicron and causes a severe disease leading to around 80% mortality. This suggests that mutations outside of spike are major determinants of the attenuated pathogenicity of Omicron in K18-hACE2 mice. Further studies are needed to identify those mutations and decipher their mechanisms of action. –Biorxiv(LINK)
